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KMID : 0378019860290040103
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New Medical Journal
1986 Volume.29 No. 4 p.103 ~ p.107
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The Further Study of Possibility of Cancer Diagonosis by NMR Measurement of Urine(Ⅲ)
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Kim Y.J.
Lee J.H.
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Abstract
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It was reported" that the characteristic A. Samples
cancer urine NMR signal regarded as a The cancer and non-cancer urine samples*
cancer marker lied within the range of 3. 00 are furnished by the obstetrics department ±0.06ppm to 3.09±0.06ppm which were the of Hanyand University Hospital in Seoul. All proton NMR signals of the NH compound the samples are evaporated and kept in a elements of aromatic amines and which were freezer so as not to be decomposed before concretely identified as the substance of
tyrosine excreted in the urine. The identif i- measuring.
cation of the substance was done by use of B. Measurement
the reagent2´ developed by a mixture of D2o is used as a solvent. The NMR sample protein being partly deficient in amino acid tube is filled with 0. 5 c.c. of the solvent and Millon indicator used as a test for phe- mixed with the evaporated samples to meas- measnolic compounds or tyrosine. In this paper, ure the proton NMR frequency-shift signals a further attempt has been made to recon- using the Varian EM-360 60 MHz high resol firm the range of the signals by performing ution NMR spectrometer. TMS (tetramethy the NMR experiments on some other kinds Isilane) is used as a reference standard which of cancer urine such as the urine of the is taken to be Oppm for the measurement. cervix and endometrial cancer patients. Each of the NMR signal distributions is
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